of cell membranes and friction coefficients between some components for a motile membrane of a random shape [4, 5]
Theoretical studies are combined with the experiments on a visual observation of freeze-thawing processes of cell suspensions using special devices to a light microscope.
At the department there has been elaborated a unique cryomicroscopic complex for a visual study within a wide temperature range of the kinetics of physical and chemical processes, accompanying freeze-thawing of biological objects, kinetics of cell osmotic behavior at various cryorpeservation stages, cell permeability for cryoprotectants and water [6-9].
We perform the investigations on evaluating the mode of erythrocytes' membrane shift , peculiarities of erythrocytes transformation in different media [11-13], dilatometric studying of phase-structural transformations in cryoprotective media, cell suspensions and tissues within the range of low temperatures .
There has also been elaborated the experimental method for a quick determination of the coefficients for erythrocytes membrane permeability for electrically neutral substances [15-16] and erythrocytes distribution in the population on sphericity index , based on measuring the intensity of scattered by cells light. There was proved diagnostic efficacy of cell parameters studied for differentiation of normal and pathological states in blood, in particular, at hyper- and hypothyrosis, as well as at Diabetes mellitus [18, 19].
There have been studied the mechanisms for erythrocytes membrane permeability for the series of substances and the regularities were established for functioning of parallel ways of their penetration: through lipid bilayer and via protein channels of a certain size. There are determined the factors influencing the molecule permeability by that of another way [20-22].